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Share This Using a nanowire-based force probe, scientists have developed a technique to isolate individual cells of the bacterium Mycobacterium smegmatis from soil, paving the way to study many genes at a single-cell level. The technique uses soft nanowire-based force probes to measure the mechanical properties of the individual cells, and to repel individual cells from one another. This single-cell tracking system might be useful for drug discovery and vaccine development. Related Articles Cell mechanical properties vary depending on cell types, stages of cell cycle, and conditions that can influence cell responses to drugs. Most cells have a mean Young's modulus of ∼1 MPa, but this can vary by several hundred percent. Because of this variability, a single-cell mechanical property has rarely been determined. "For a long time, we have assumed that cells have the same mechanical properties, but that is not necessarily true," says senior author Laura Vermes, Ph.D., associate professor of pathology and director of the Integrated Microscopy Core at the Washington University School of Medicine in St. Louis. "Single-cell mechanical properties are particularly important because they can change rapidly, as they do during the cell cycle. This variability in cell mechanical properties could lead to misinterpretations of data." To get at this variability, the scientists created a method to isolate individual cells of M. smegmatis from soil by measuring the mechanical properties of the cells. Using soft nanowire-based force probes, the researchers measured the mechanical properties of single M. smegmatis cells with nanoscale resolution Docklight Crack + (Updated 2022) Docklight Serial Key is a comprehensive simulation and testing tool for serial communication devices. 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